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Photochemical model of Photodynamic Therapy applied to skin diseases by a topical photosensitizer

机译:局部光敏剂应用于皮肤疾病的光动力疗法的光化学模型

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摘要

Photodynamic Therapy (PDT) provides a non-invasive, efficient and safe treatment for skin diseases with good cosmetic results. These characteristics make this technique more advantageous than radiotherapy or chemotherapy, which present limitations in a big number of lesions, are painful in many cases and produce non-satisfactory cosmetic results. We present the clinical results obtained at present by this optical technique and a photochemical model of the PDT process applied to the skin by means of a topical photosensitizer, in order to find the optimal PDT parameters. Optical propagation inside the tissue is calculated by means of the three dimensional Beer-Lambert law, due to its facility to be integrated in the differential equations system used to model the photochemical processes involved. With this information it is possible to obtain an initial estimation about the optimal drug dose and the optical power required.
机译:光动力疗法(PDT)为皮肤疾病提供了一种无创,有效和安全的治疗方法,并具有良好的美容效果。这些特征使该技术比放射疗法或化学疗法更具优势,放射疗法或化学疗法在许多病灶中存在局限性,在许多情况下是痛苦的并且产生不令人满意的美容效果。我们介绍了目前通过这种光学技术获得的临床结果以及通过局部光敏剂应用于皮肤的PDT过程的光化学模型,以找到最佳的PDT参数。由于其可以集成到用于对涉及的光化学过程进行建模的微分方程系统中,因此可以通过三维比尔-朗伯定律来计算组织内部的光传播。利用该信息,可以获得关于最佳药物剂量和所需光功率的初始估计。

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